Clinical use of Griseofulvin fine particle

Mycological and clinical evaluation of griseofulvin for chronic onychomycosis.

When griseofulvin became available in 1959 a critical evaluation of its use in chronic tinea of the nail was begun. Since then 122 patients have been treated with a standard dose§ (0.5 g. t.d.s. for one month followed by 0.5 g. b.d.) for a minimum of six months and 74 for two years. As the trial progressed it became evident that a longer course of treatment was required than that suggested in e...

Dynamics in fine particle magnets

Several magnetic fine particle systems have been studied with selective excitation double Mössbauer ~SEDM! spectroscopy. Static disorder, collective excitations, and superparamagnetic spin flips are all detected and their contributions quantified. Zero-field muon spin relaxation spectroscopy has been used to confirm these observations in one sample. A theoretical description of SEDM spectra in ...

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

The Isothermal Remanence of Fine Particle Systems

A numerical model based upon the "Stoner-Wohlfarth theory" has been developed to predict Isothermal Remanent Magnetisation (IRM) curves for a system of fine particles with uniaxial anisotropy. This paper reports the predictions of our model for the effects of easy axes alignment on the IRM curve. We have also investigated the effect of the standard deviation after the application of a non-satur...